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Human Protein Atlas (HPA)

| Purpose | URL Pattern | |---|---| | Gene data by Ensembl ID | `/{ENSEMBL_ID}.json` | | Gene data by symbol | `/{GENE_NAME}.json` | | Search (JSON) | `/search/{QUERY}?format=json` | | Search (XML) | `/search/{QUERY}?format=xml` |

Claude Code Knowledge Pack7/10/2026

Overview

Human Protein Atlas (HPA)

Base URL

https://www.proteinatlas.org

Auth

No API key required.

Key Endpoints

PurposeURL Pattern
Gene data by Ensembl ID/{ENSEMBL_ID}.json
Gene data by symbol/{GENE_NAME}.json
Search (JSON)/search/{QUERY}?format=json
Search (XML)/search/{QUERY}?format=xml

Example Calls

# Gene data by Ensembl ID
https://www.proteinatlas.org/ENSG00000141510.json

# Gene data by symbol
https://www.proteinatlas.org/TP53.json

# Search
https://www.proteinatlas.org/search/TP53?format=json

Response Format (JSON, gene endpoint)

{
  "Gene": "TP53",
  "Gene synonym": ["p53", "LFS1"],
  "Ensembl": "ENSG00000141510",
  "Gene description": "tumor protein p53",
  "Uniprot": ["P04637"],
  "Chromosome": "17",
  "Protein class": ["Transcription factors"],
  "RNA tissue specificity": "Low tissue specificity",
  "Subcellular location": ["Nucleoplasm"],
  "Pathology prognostics": [...]
}

Bulk Downloads

For large-scale work, use TSV files from https://www.proteinatlas.org/about/download:

  • normal_tissue.tsv — IHC tissue expression
  • rna_tissue_consensus.tsv — RNA consensus
  • subcellular_location.tsv
  • pathology.tsv — cancer prognostics

Rate Limits

No published limits. Be reasonable. Prefer bulk downloads for large queries.